Exploring the Chemical Properties of PMK Glycidate: A Key Intermediate in Organic Synthesis
Exploring the Chemical Properties of PMK Glycidate: A Key Intermediate in Organic Synthesis


PMK glycidate, also known as para-methoxyphenylglycidate, is a crucial intermediate in the synthesis of pharmaceuticals, fragrances, and fine chemicals. Its chemical properties and synthetic versatility make it a valuable building block in organic synthesis.

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Chemical Structure:

  • Molecular Formula: C₁₁H₁₂O₅
  • Chemical Structure:
  • Functional Groups: Ester, epoxide

Physical Properties:

  • Appearance: PMK glycidate typically appears as a white to off-white crystalline powder.
  • Melting Point: It has a melting point ranging from 76-80°C, depending on the purity and crystal form.
  • Solubility: PMK glycidate is sparingly soluble in water but soluble in many organic solvents such as ethanol, acetone, and ether.

Chemical Properties:

  • Reactivity: PMK glycidate undergoes various chemical reactions, including hydrolysis, epoxidation, and esterification, enabling its conversion into diverse chemical derivatives.
  • Epoxidation: The epoxide moiety in PMK glycidate makes it susceptible to epoxidation reactions, yielding epoxy compounds with potential applications in polymer chemistry.
  • Ester Hydrolysis: Hydrolysis of the ester group in PMK glycidate leads to the formation of phenolic compounds, opening avenues for the synthesis of pharmaceutical intermediates.


  • Drug Precursor: PMK glycidate serves as a key intermediate in the illicit synthesis of MDMA (3,4-methylenedioxymethamphetamine) and related psychoactive compounds.
  • Flavor and Fragrance: It finds use in the synthesis of flavor and fragrance compounds due to its ability to introduce aromatic functionality into organic molecules.
  • Research Reagent: PMK glycidate serves as a valuable research reagent in academic and industrial laboratories for its role in organic synthesis and chemical derivatization.

Safety Considerations:

  • Regulatory Status: PMK glycidate is a controlled substance in many jurisdictions due to its association with the illicit production of controlled substances.
  • Handling Precautions: Proper safety measures, including personal protective equipment and ventilation, should be observed when handling PMK glycidate due to its potential health hazards and regulatory scrutiny.


PMK glycidate emerges as a pivotal intermediate in organic synthesis, offering synthetic versatility and applications across diverse industries. By understanding its chemical properties and reactivity, researchers can harness the potential of PMK glycidate in drug discovery, flavor chemistry, and materials science, contributing to advancements in science and technology.

Information for preparing this article was taken from the site: https://www.federalregister.gov/documents/2021/05/10/2021-09697/designation-of-34-mdp-2-p-methyl-glycidate-pmk-glycidate-34-mdp-2-p-methyl-glycidic-acid-pmk

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